Publications
Illuminating Cytochrome P450 Binding: Ru (II)-Caged Inhibitors of CYP17A1 Li, A., Yadav, R., White, J.K., Herroon, M.K., Callahan, B.P., Podgorski, I., Turro, C., Scott, E.E., and Kodanko, J.J. (2017) Illuminating Cytochrome P450 Binding: Ru (II)-Caged Inhibitors of CYP17A1 Chem. Comun. In Press.
Structural insights into the function of steroidogenic cytochrome P450 17A1 Yadav, R., Petrunak, E.M., Estrada, D.F., and Scott, E.E. (2016) Structural insights into the function of steroidogenic cytochrome P450 17A1 Mol. Cell. Endocrinol. 7207:30330-30336.
Promising tools in prostate cancer research:  Selective non steroidal cytochrome P450 17A1 inhibitors Bonomo, S., Hansen, C.H., Petrunak, E.M., Scott, E.E., Styrishave, B., Jorgensen, F. S., and Olsen, L. (2016) Promising tools in prostate cancer research: Selective non steroidal cytochrome P450 17A1 inhibitors Nat. Sci. Reports 6:29468-29479.
The role of protein-protein and protein-membrane interactions on P450 function Scott, E.E., Wolf, R.C., Otyepka, M., Humphreys, S.C., Reed, J.R., Henderson, C.J., McLaughlin, L.A., Paloncýová, M., Navrátilová, V., Berka, K., Anzenbacher, P., Dahal, U.P. Barnaba, C., Brozik, J.A., Jones, J.P., Estrada, D.F., Laurence, J.S., Park, J.W., and Backes, W.L. (2016) The role of protein-protein and protein-membrane interactions on P450 function Drug Metab. Dispos. 44:576-590.
Cytochrome P450 17A1 interactions with the FMN domain of its reductase as characterized by NMR Estrada, D.F., Laurence, J.S., and Scott, E.E. (2015) Cytochrome P450 17A1 interactions with the FMN domain of its reductase as characterized by NMR J. Biol. Chem. 291:3390-4003.
Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates Petrunak, E.M., DeVore, N.M., Porubsky, P.R. and Scott, E.E. (2014) Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates J. Biol. Chem. 289:32952-32964.
Human Cytochrome P450 17A1 Conformational Selection: Modulation by Ligand and Cytochrome b5 Estrada, D.F., Skinner, A.L., Laurence, J.S., and Scott, E.E. (2014) Human cytochrome P450 conformational selection:  Modulation by ligand and cytochrome b5 J. Biol. Chem. 289:14310-14320.
Correlating Structure and Function of Drug Metabolizing Enzymes:  Progress and Ongoing Challenges Johnson, E.F., Connick, J.P., Reed, J.R., Backes, W.L., Desai, M.C., Xu, L., Estrada, D.F., Laurence, J.S. and Scott, E.E. (2014) Correlating Structure and Function of Drug Metabolizing Enzymes: Progress and Ongoing Challenges Drug Metab. Dispos. 42:9-22.
Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism Walsh, A.A., Szklarz, G.D. and Scott, E.E. (2013) Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism J. Biol. Chem. 288:12932-12943.
Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users Blake, L.C., Roy, A., Neul, D., Schoenen, F.J., Aubé, J. and Scott, E.E. (2013) Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users Pharm. Res. 30:2290-2302.
Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR Estrada, D.F., Laurence, J.S., and Scott, E.E. (2013) Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR J. Biol. Chem. 288:17008-17018.
Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes Stephens, E.S., Walsh, A.A., and Scott, E.E. (2012) Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes Drug Metab. Dispos. 40:1797-802.
Cytochrome P450 17A1 structures with prostate cancer drugs abiraterone and TOK-001 DeVore, N.M. and Scott, E.E. (2012) Cytochrome P450 17A1 structures with prostate cancer drugs abiraterone and TOK-001 Nature 482:116-119.
 Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine DeVore, N.M., Meneely, K.M., Bart, A.G., Stephens, E.S., Battaile, K.P., and Scott, E.E. (2012) Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine FEBS J. 279:1621-31 .
Crystal structure of histamine dehydrogenase from Nocardioides simplex Reed, T., Lushington, G.H., Xia, Y., Hirakawa, H., Mure, M., Scott, E.E., and Limburg, J. (2010) Crystal structure of histamine dehydrogenase from Nocardioides simplex J. Biol. Chem. 285:25782-25791.
Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode Porubsky, P.R., Battaile, K.P., and Scott, E.E. (2010) Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode J. Biol. Chem. 285:22282-22290.
Targeting drug metabolizing enzymes for effective chemoprevention and chemotherapy Swanson, H.I., Njar, V.C.O., Yu, Z., Castro, D.J., Gonzalez, F.J., Williams, D.E., Huang, Y., Kong, A-N.T., Doloff, J.C., Ma, J., Waxman, D.J., and Scott, E.E. (2010) Targeting drug metabolizing enzymes for effective chemoprevention and chemotherapy Drug Metab. Dispos. 38:539-544.
Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis Culpepper, M.A., Scott, E.E., and Limburg, J. (2010) Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis Biochemistry 49:124-133.
 Key residues controlling binding of diverse ligands to human cytochrome P450 2A Enzymes DeVore, N.M., Smith, B.D., Wang, J.L., Lushington, G.H., and Scott, E.E. (2009) Key residues controlling binding of diverse ligands to human cytochrome P450 2A Enzymes Drug Metab. Dispos. 37:1319-1327.
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes DeVore, N.M., Smith, B.D., Urban, M.J., and Scott, E.E. (2008) Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes Drug Metab. Dispos. 36:2582-2590.
Expression, purification and crystallization and preliminary X-ray studies of histamine dehydrogenase from Nocardiodes simplex Reed, T.M., Hirakawa, H., Mure, M., Scott, E.E., and Limberg, J. (2008) Expression, purification and crystallization and preliminary X-ray studies of histamine dehydrogenase from Nocardiodes simplex Acta Crystallogr. F. 64:785-787.
p-Dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/Vis-MS/MS identification of indoles Porubsky, P.R., Scott, E.E., and Williams, T.D. (2008) p-Dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/Vis-MS/MS identification of indoles Arch. Biochem. Biophys. 475:14-17.
Functional characterization of CYP2A13 polymorphisms Schlicht, K.E., Michno, N., Smith, B.D., Scott, E.E., and Murphy, S.E. (2007) Functional characterization of CYP2A13 polymorphisms Xenobiotica 37:1439-1349.
Structure of the human lung cytochrome P450 2A13 Smith B.D., Sanders J.L., Porubsky P.R., Lushington G.H., Stout C.D., and Scott, E.E. (2007) Structure of the human lung cytochrome P450 2A13 J. Biol. Chem. 282:17306-17313.
Structures of cytochrome P450 3A4 Scott E.E. and Halpert J.R. (2005) Structures of cytochrome P450 3A4 Trends in Biochem. Sci. 30:5-7.